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鞠鑫

发布日期:2024-03-16    浏览次数:

【硕士生导师简介】

  

鞠鑫

 

  

出生年月

1982/08

  

博士研究生

  

讲师

  


 

18550209892

电子邮箱

juxin@mail.usts.edu.cn

【个人简介】

本科和研究生毕业于华东理工大学,曾任职于酶催化剂研发和生产企业,2012年进入苏州科技大学工作,现担任化学生物与材料工程学院生物系副主任。

【研究领域】

1 酶工程

2 生物质酶促转化

【项目与获奖】

(一)、承担的科研项目

2017-01至今,类芽孢杆菌sp.LLZ1纤维素酶多样性及其在离子液体中的失活与强化机制(21676173),国家自然科学基金面上项目,在研,第二完成人

2016-012018-12,基于MEK1/2靶点的人生内生假单胞杆菌活性成分筛选及抗肿瘤活性研究(BK20150286),江苏省自然科学基金青年项目,结题,主持

2014-012017-12 环境压力下球头三型胞菌Hog1调控多元醇产生及其代谢转换研究(21376156) 国家自然科学基金面上项目,结题,第二完成人

(二)、获奖成果

药用还原氧化酶和辅酶的研发及产业化,苏州市科技局 科技进步三等奖,2016.1

张家港市自然科学优秀学术论文一等奖 张家港市科技局,2014.11

【论文、论著及授权专利】

发表论文:

Hengtao Tao#, Xin Ju#, Jing Zhao,   Liangzhi Li*, Engineering ribose-5-phosphate isomerase B from a central   carbon metabolic enzyme to a promising sugar biocatalyst, Appl. Microbiol.   Biotechnol. 2021, 105: 509-523

Xiaofeng Zhang, Xinqi Xu, Xuemei Yao, Rong Wang, Hengtao Tang, Xin   Ju*, Liangzhi Li*; Exploring Multifunctional Residues of   Ribose-5-phosphate Isomerase B from Ochrobactrum sp. CSL1 Enhancing   Isomerization of D-Allose, J. Agric. Food Chem. 2020, 68(11), 3539–3547

Wei Yang, Huan Fan, Min Zhou, Zheng Zhou, Lishi Yan, Xin Ju*,   Liangzhi Li*, Synergistic effect of ionic liquid and surfactant for enzymatic   hydrolysis of lignocellulose by Paenibacillus sp. LLZ1 cellulase, Biomass   Bioenerg. 2020, 142: 105760

Min Zhou, Xin Ju, Zheng Zhou, Lishi Yan, Jiajia Chen,   Xuemei Yao, Xinqi Xu, Liang-Zhi Li*, Development of an immobilized cellulase system   based on metal-organic frameworks for improving ionic liquid tolerance and in   situ saccharification of bagasse, ACS Sustainable Chem. Eng. 2019,   7, 19185–19193

Zheng Zhou, Xin Ju, Min Zhou, Xinqi Xu, Jiaolong Fu,   Liangzhi Li*, An enhanced ionic liquid-tolerant immobilized cellulase system   via hydrogel microsphere for improving in situ saccharification of biomass, Bioresour.   Technol. 2019, 294, 122146

Min Zhou#, Xin Ju#, Liang-Zhi Li*, Lishi   Yan, Xinqi Xu, Jiajia Chen, Immobilization of cellulase in the non-natural   ionic liquid environments to enhance cellulase activity and functional   stability, Appl. Microbiol. Biotechnol. 2019, 103, 2483–2492

Dongxue Hu#, Xin Ju#, Liang-Zhi Li*,   Cuiying Hu, Lishi Yan, Tianyun Wu, Jiaolong Fu, Ming Qin, Improved in situ   saccharification of cellulose pretreated by dimethyl sulfoxide/ionic liquid   using cellulase from a newly isolated Paenibacillus sp. LLZ1, Bioresour.   Technol. 2016, 201, 8–14

Xin Ju, Jianyong Li, Maoqi Hou, Junhua   Tao*, A lipase-catalyzed process for green synthesis of temsirolimus, Eng.   Life Sci. 2015, 15, 229–233

Xin Ju, Yuanyuan Tang, Xiaoliang   Liang, Maoqi Hou, Zhonghui Wan, Junhua Tao*, Development of a biocatalytic process   to prepare (S)-N-Boc-3-hydroxypiperidine, Org. Process Res.   Dev. 2014, 18, 827–830

Xin Ju, Huilei Yu, Jiang Pan, Jianhe   Xu*, Improved production of Pseudomonas sp. ECU1011 acetyl esterase by   medium design and fed-batch fermentation, Bioprocess Biosyst. Eng. 2012,   35, 323–331

赵晶,鞠鑫,潘江,李春秀,王敏杰,许建和*,毛白杨环氧水解酶的异源表达及其在催化拆分手性环氧化物中的应用,催化学报, 2012, 33(2), 302–307

Xin Ju, Jiang Pan, Huilei Yu, Chunxiu   Li, Jianhe Xu*, Improving Pseudomonas sp. esterase performance by   engineering approaches for kinetic resolution of 2-acetoxyphenylacetic acids,   Biochem. Eng. J. 2011, 57, 63–68

Xin Ju, Huilei Yu, Jiang Pan, Dongzhi   Wei, Jianhe Xu*, Bioproduction of chiral mandelate by enantioselective   deacylation of α-acetoxyphenylacetic acid using whole cells of newly isolated   Pseudomonas sp. ECU1011. Appl. Microbiol. Biotechnol. 2009, 86,   83–91

鞠鑫,潘江,许建和*,绿豆环氧水解酶催化对硝基苯乙烯氧化物的对映归一性水解,催化学报2008, 29(08), 696–700

发表专著:

Kui Chan, Ju Xin, Xiaoliang Liang, Lizeng Peng, Bin Sun, Junhua   Tao*, EnzymeWorks: Recent Advances in Enzyme Engineering for Chemical   Synthesis, Chapter 7 from <Biocatalysis: An Industrial Perspective>, edited   by Gonzalo de Gonzalo and   Pablo Domínguez de María, 2017, RSC Publishing

Xin Ju, Jie Zhang, Kui Chan, Xiaoliang   Liang, Junhua Tao*, and Jianhe Xu*, Application of High-Throughput Screening   in Biocatalysis, Chapter 4   from <Applied Biocatalysis: From Fundamental Science to Industrial   Applications>, edited by Hilterhaus, Lutz et al., 2016, Wiley-VCH

授权专利:

中国专利 一种左旋肉碱的合成方法,1037090582015.09授权

中国专利 6-氰基-3R,5R-二羟基己酸叔丁酯的生物制备方法,1030140802015.02授权

中国专利 (R)-4-氰基-3-羟基丁酸乙酯的生物制备方法,1030140822014.08授权

中国专利 一种(S)-4--3-羟基丁酸乙酯的生物制备方法,1026050112013.11授权

中国专利 一种手性β-羟基酯类化合物的酶催化合成方法授权,1026345462013.10授权

中国专利 一种L-2-氨基丁酸的生物制备方法,1026050142013.05授权

梁晓亮;庄季昌,一种氧化型辅酶I的制备方法,1026050262013.04授权

中国专利 一种假单胞菌酯酶及其用于制备光学纯扁桃酸及其衍生物的用途,1015385422009.12授权

 

以上资料更新日期:202103