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张星

发布日期:2024-03-01    浏览次数:

【硕士生导师简介】

   

张星

   

出生年月

1984.09.09

   

博士研究生

   

讲师

   

   

15862386021

电子邮箱

xzhang2022@usts.edu.cn

【个人简介】

本科和硕士毕业于苏州大学医学部生物化学与分子生物学专业,博士毕业于浙江大学医学院细胞生物学专业。20178-20189月公派赴韩国首尔大学生物科学学院进行访学研究。202212月就职于苏州科技大学。近年来教学方面,主要承担《食品营养学》通识课的教学,参与《细胞工程》和《人体解剖生理学》专业课的教学等。科研方面在国内外期刊发表SCI论文30余篇。主持国家自然科学基金青年基金项目、江苏省自然科学基金青年基金项目、中国博士后科学基金面上项目、江苏省高校自然科学基金、苏州市自然科学基金资助、资源昆虫高效养殖与利用全国重点实验室开放课题和苏州大学血液和血管疾病诊疗药物技术教育部工程研究中心开放课题参与国家863973项目课题、国家重点研发计划项目等研究工作。

【研究领域】

目前,主要从事功能基因组学、生物制药、病毒分子生物学,肿瘤免疫,病毒与宿主互作等相关研究。

【项目与获奖】

(一)、承担的科研项目

 主持和参与项目基金:

1.          circRNA-000010编码小肽VSP39抑制NF-κB信号通路促进病毒增殖的分子机制,20241-202612月,国家自然科学基金青年项目,主持

2.          IFN-γ响应释放VEGFPDGF的新型含蜘蛛丝蛋白的丝素蛋白膜在皮肤损伤中血管化作用,202212-202412月,苏州大学血液和血管疾病诊疗药物技术教育部工程研究中心,主持

3.          阅读蛋白   BmYTHDF3降解 m6A 修饰的ie-1基因mRNA抑制BmNPV增殖的分子机制, 202212-202511月,西南大学资源昆虫高效养殖与利用全国重点实验,主持

4.          BmCPV编码RNAi抑制子NSP8调节病毒增殖的分子机制,20195-20215月,中国博士后基金会,主持

5.          基于高通量测序筛查肺结核miRNA标志物及功能研究,20157-20186月,江苏省科技厅,主持

6.          乙肝病毒vcircRNA-001靶向miRNA-6124/ST7信号轴在肝细胞癌发生中的作用机制,20197-20216月,江苏省教育厅,主持

7.          BmCPV编码RNAi抑制子NSP8调节病毒增殖的分子机制及抗病毒靶点研究,20199-20226月,苏州市科技局,主持

8.          BmCPV编码病毒小肽vSP27调控ROS-NF-κB信号通路抑制病毒感染机制,20201-202312月,国家自然科学基金委,参与

 

获奖成果

12023年获得全国商业联合会科技进步奖,二等奖,排名3

 

【论文、论著及授权专利】

主要代表性论文:

1.          Xing Zhang, Yiming   Huo, Yifei Kong, Wenlin Zhou, Feiju Qin, Xiaolong Hu. Effects of short-term   florfenicol exposure on the gene expression pattern, midgut microbiota, and   metabolome in the lepidopteran model silkworm (Bombyx mori). Science of the   Total Environment 912 (2024) 169099. (第一作者)

2.          Zhang X, Shao W, Huo   Y, Kong Y, Zhang W, Li S, Zhou W, Wu X, Qin F, Hu X. The effects of   short-term dietary exposure to SiO2 nanoparticle on the domesticated   lepidopteran insect model silkworm (Bombyx mori): Evidence from the   perspective of multi-omics. Chemosphere. 2023, 323:138257. (第一作者)

3.          Liu L, Shi Y, Zhang P, Zhang X.   Integration analysis of miRNA-mRNA expression exploring their potential roles   in intrahepatic cholangiocarcinoma. Sci Rep. 2023, 13(1):8362.(通讯作者)

4.          Zhou W, Zhang X, Chen X, Wu X, Ye A, Cao   J, Hu X. Short-term triphenyltin exposure alters microbial homeostasis in the   silkworm (Bombyx mori) midgut. Sci Rep. 2023, 13(1):15183.(并列第一)

5.          Wu X, Zhang X, Chen X, Ye A, Cao J, Hu X,   Zhou W. The effects of polylactic acid bioplastic exposure on midgut   microbiota and metabolite profiles in silkworm (Bombyx mori): An integrated   multi-omics analysis. Environ Pollut. 2023, 334:122210.(并列第一)

6.          Zhou W, Weng Y, Liu Q, Wang C, Zhang YQ, Zhang   X, Ye A. Dietary administration with hydrolyzed silk sericin improves the   intestinal health of diabetic rats. Front Microbiol. 2023, 14:1074892.(并列通讯)

7.          Chen X, Zhang X, Ye A, Wu X, Cao J,   Zhou W. Toxic effects of triphenyltin   on the silkworm Bombyx mori as a lepidopterous insect model. Ecotoxicol Environ Saf. 2022, 247:114245.(并列第一)

8.          Zhang X, Zhang   Y, Pan J, Gong C, Hu X. Identification and   Characterization of BmNPV m6A Sites and Their Possible Roles During Viral   Infection. Frontiers in Immunology. 2022, 13:869313.(第一作者)

9.          Xing Zhang, Zi   Liang, Chenglong Wang, Zeen Shen, Sufei Sun, Chengliang Gong and Xiaolong Hu.   Viral circular RNAs and their possible roles in virus-host interaction,   Frontiers in Immunology. 2022, 13:939768.(第一作者)

10.       Yunshan Zhang, XingZhang, KunDai, Min Zhu,   Zi Liang, Jun Pan, Ziyao Zhang, Renyu Xue, Guangli Cao, Xiaolong Hu,   ChengliangGong. Bombyx mori Akirin hijacks a viral peptide vSP27 encoded by   BmCPV circRNA and activates the ROS-NF-κB pathway against viral infection.   International Journal of Biological Macromolecules. 2022, 194:223-232.并列第一)

11.     Zhang Y, Zhu M, Zhang X, Dai K, Liang Z, Pan J, Zhang Z,   Cao M, Xue R, Cao G, Hu X, Gong C. Micropeptide   vsp21 translated by Reovirus circular RNA 000048 attenuates viral   replication. Int J Biol Macromol. 2022 Jun 1;209(Pt   A):1179-1187.并列第一

12.     Liang Z, Xue R, Zhang X, Cao M, Sun S, Zhang Y, Zhu M,   Zhang Z, Dai K, Pan J, Cao G, Wang C, Hu X, Gong C. β-Arrestin 2 acts an adaptor protein that facilitates   viral replication in silkworm. Int J Biol Macromol.   2022 May 31;208:1009-1018.并列第一

13.       Xing Zhang, Yunshan Zhang, Jun Pan, Min Zhu, Zi Liang, Zeen Shen, Kun Dai, Bingyu Yan, Yaping Dai, Renyu Xue, Guangli Cao, Xiaolong Hu, Chengliang Gong. Proteomic analysis of the exosomes secreted   from Ctenopharyngodon idellus kidney cells infected with grass carp reovirus   reveals their involvement in the cellular responses to viral infection. Fish   physiology and biochemistry. 2021,47(4):857-867.第一作者)

14.       Min Zhu, Xing Zhang, Jun Pan, Hanxue Zhu,   Ziyao Zhang, Zi Liang, Guangli Cao, Xiaolong Hu, Renyu Xue, Chengliang Gong.   Tight junction protein claudin-2 promotes cell entry of Bombyx mori   cypovirus. Appl Microbiol Biotechnol. 2021 Aug;105(14-15):6019-6031.并列第一)

15.       Xiu Shi, Yaxin Zhang, Tianchen Zhu, Nan Li, Sufei   Sun, Min Zhu, Jun Pan, Zeen Shen, Xiaolong Hu, Xing Zhang, Chengliang   Gong. Response to Bombyx mori nucleopolyhedrovirus infection in silkworm: Gut   metabolites and microbiota. Dev Comp Immunol. 2021 Dec;125:104227.并列通讯)

16.       Xing Zhang, Yunshan   Zhang, Xiu Shi, Kun Dai, Zi Liang, Min Zhu, Ziyao Zhang, Zeen Shen, Jun Pan,   Chonglong Wang, Xiaolong Hu, Chengliang Gong. Characterization of the   lipidomic profile of BmN cells in response to Bombyx mori cytoplasmic   polyhedrosis virus infection. 2020, Developmental & Comparative   Immunology, 114:103822.(第一作者)

17.       Xing Zhang, Yunshan   Zhang, Kun Dai, Zi Liang, Min Zhu, Jun Pan, Mingtian Zhang, Bingyu Yan,   Hanxue Zhu, Ziyao Zhang, Yaping Dai, Manman Cao, Yuchao Gu, Renyu Xue,   Guangli Cao, Xiaolong Hu and Chengliang Gong. N6-Methyladenosine Level in   Silkworm Midgut/Ovary Cell Line Is Associated With Bombyx mori   Nucleopolyhedrovirus Infection. Frontiers in Microbiology. 2020, 10:2988.(第一作者)

18.       Xing Zhang, Jingcai   Huang, Zeen Shen, Yan Wang, Yujun Wang, Chengliang Gong, Xiaolong Hu,   Chonglong Wang. Identification of lipidomic responses to GCRV infection in   Ctenopharyngodon idellus kidney (CIK) cells. Aquaculture, 2020, 533:736106.(第一作者)

19.       Tingting Zhang, Rui Yuan, Xing Zhang, Bo   Liu, Yang Zhou, Zi Liang, Min Zhu, Mingtian Zhang, Yunshan Zhang, Kun Dai,   Ziyao Zhang, Manman Cao, Yuchao Gu, Jun Pan, Bingyu Yan, Hanxue Zhu, Yuqun   Zhou, Yongjie Feng, Renyu Xue, Guangli Cao, Hui Chen, Xiaolong Hu, Chengliang   Gong. De novo RNA-seq   assembly and differential transcriptome analysis of Carassius auratus gibelio   after Cyprinid herpesvirus 2 infection. Aquaculture   519 (2020) 734923.(并列第一)

20.       Xing Zhang, Zi Liang,   Yunshan Zhang, Xiaolong Hu* & Ji Wang*. Comprehensive analysis of long   non-coding RNAs expression pattern in the pathogenesis of pulmonary   tuberculosis. Genomics 2020, 112: 1970-1977.(第一作者)  

21.       Jun Pan, Xing Zhang, Yunshan Zhang, Bingyu   Yan, Kun Dai, Min Zhu, Zi Liang, Yaping Dai, Mingtian Zhang, Ziyao Zhang,   Hanxue Zhu, Yuchao Gu, Manman Cao, Renyu Xue, Guangli Cao, Xiaolong Hu,   Chengliang Gong. Grass carp reovirus encoding circular RNAs with antiviral   activity. 2020, Aquaculture, 533(9–21):736135.(并列第一)

22.       Yunshan Zhang, Xing Zhang, Zi Liang, Kun Dai, Min   Zhu, Mingtian Zhang, Jun Pan, Renyu Xue, Guangli Cao, Tian Tang, Xuehong   Song, Xiaolong Hu*, ChengliangGong*. Interleukin-17 suppresses grass carp   reovirus infection in Ctenopharyngodon idellus kidney cells by activating NF-κB signaling. Aquaculture 520, 2020, 734969.(并列第一)

23.       Yunshan Zhang, Xing Zhang, Zi Liang, Min   Zhu, Mingtian Zhang, Tingting Zhang, Ziyao Zhang, Manman Cao, Yuchao Gu, Jun   Pan, Bingyu Yan, Hanxue Zhu, Renyu Xue, Guangli Cao, Yuan Gao, Xiaolong Hu*,   ChengliangGong*. Expression pattern and regulatory network of gibel carp   (Carassius gibelio) miRNAs and their putative target genes in response to   CyHV-2 infection. Aquaculture 523, 2020, 735178.(并列第一)

24.     Xing Zhang, Zi Liang, Yunshan Zhang, Min   Zhu, Yueping Zhu, Sumei Li, Weifeng Zhao, Xiaolong Hu & Ji Wang. Specific   PIWI-interacting small noncoding RNA expression patterns in pulmonary   tuberculosis patients. Epigenomics. 2019, 1779-1794.(第一作者)

25.       Xiaolong Hu, Yaping Dai, Xing Zhang, Kun Dai, Bo   Liu, Rui Yuan, Yongjie Feng, Zi Liang, Min Zhu, Mingtian Zhang, Yunshan   Zhang, Ziyao Zhang, Manman Cao, Yuchao Gu, Jun Pan, Bingyu Yan, Hanxue Zhu,   Renyu Xue, Guangli Cao, Hui Chen, Yujun Wang, Chengliang Gong. Identification   and characterization of novel type of RNAs, circRNAs in crucian carp   Carassius auratus gibelio. Fish and Shellfish Immunology 94 (2019) 50–57.(并列第一)

26.       Zhang X, Zhu M, Hu X.   Integrated miRNA and mRNA expression profiling to identify mRNA targets of   dysregulated miRNAs in pulmonary tuberculosis. Epigenomics. 2018,   10(8):1051-1069.(第一作者)

27.       Zhang X, Zhu M, Yang   R, Zhao W, Hu X, Gan J. Identification and comparison of novel circular RNAs   with associated co-expression and competing endogenous RNA networks in   pulmonary tuberculosis. Oncotarget. 2017, 8(69):113571-113582.(第一作者)

28.       Zhang X, Li Y, Li X,   Zhang W, Pan Z, Wu F, Wang C, Chen Z, Jiang T, Xu D, Ping Z, Liu J, Liu C, Li   Z, Li JC. Association of the miR-146a, miR-149, miR-196a2 and miR-499   polymorphisms with susceptibility to pulmonary tuberculosis in the Chinese   Uygur, Kazak and Southern Han populations. BMC Infect Dis. 2015, 15:41.(第一作者

29.       Zhang X, Guo J, Fan   S, Li Y, Wei L, Yang X, Jiang T, Chen Z, Wang C, Liu J, Ping Z, Xu D, Wang J,   Li Z, Qiu Y, Li JC. Screening and identification of six serum microRNAs as   novel potential combination biomarkers for pulmonary tuberculosis diagnosis.   PLoS One. 2013, 8(12):e81076.(第一作者)

30.       Zhang X, Li X, Zhang   W, Wei L, Jiang T, Chen Z, Meng C, Liu J, Wu F, Wang C, Li F, Sun X, Li Z, Li   JC. The novel human MRC1 gene polymorphisms are associated with   susceptibility to pulmonary tuberculosis in Chinese Uygur and Kazak   populations. Mol Biol Rep. 2013, 40(8):5073-83.(第一作者)

 

指导学生获奖:

1.          全国大学生生命科学竞赛(2023,创新创业类),国家级,三等奖

2.          “苏豪杯”第五届全国大学生蚕桑生物技术创新大赛, 2023, 省部级, 一等奖

3.          第十二届“挑战杯”江苏省大学生创业计划竞赛,2022年,省部级,银奖

4.          全国大学生生命科学竞赛(2022,创新创业类),国家级,一等奖

5.          全国大学生生命科学竞赛(2021,创新创业类),国家级,一等奖

6.          第七届中国国际“互联网+”大学生创新创业大赛,2021年,国家级,铜奖

7.          第七届江苏省“互联网+”大学生创新创业大赛,2021年,省部级,一等奖

8.          “陌桑杯”第三届全国大学生蚕桑生物技术创新大赛, 2020, 省部级, 二等奖

 

代表性授权专利:

1.          张星,   朱敏, 胡小龙. lncRNAs作为活动性肺结核病特异性标志物的应用,专利号: CN201710960636.4   

2.          李继承, 张星.一种活动性肺结核病特异的血清miRNAs的制备方法,专利号: ZL 2012 1 0171919. 8.

3.          李继承, 张星.一种检测活动性肺结核病的试剂盒,专利号: ZL 2012 1 0338287. X.

4.          胡小龙, 张星, 梁子, 沈泽恩, 朱天辰, 贡成良.一种抗病毒纳米材料及其应用,专利号: ZL 2021 1 1322681.X

5.          贡成良, 胡小龙, 王崇龙, 李楠, 张星, 朱敏, 童新宇, 邱群婻. 一种含多种蜘蛛腺丝蛋白的高强度蚕丝及其制备方法. 专利号:CN202210482497.X

以上资料更新日期:20242